MARROW TRANSPLANTATION FOR RETICULAR DYSGENESIS RESULTING IN IMMUNOLOGIC RECONSTITUTION WITHOUT MYELOID RECONSTITUTION
نویسندگان
چکیده
منابع مشابه
Immunologic Reconstitution After Haploidentical Bone Marrow Transplantation for Immune Deficiency Disorders: Treatment of Bone Marrow Cells
Patients with congenital T lymphocyte deficiency disorders received transplants with parental bone marrow depleted of mature T cells by the use of an anti-T cell monoclonal antibody (CT-2) and complement. Our results with 16 consecutive patients (20 transplants) showed rapid engraftment of donor cells; cytoreduction (busulfan. cytosine arabinoside [ara-CJ. cyclophosphamide) was used in six tran...
متن کاملFull Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency
Bone marrow transplantation in human X-linked severe Normal percentages of T cells and T-cell mitogenic recombined immunodeficiency (XSCID) without pretransplant sponses were attained by 3 months posttransplant. CD3 T conditioning results in engraftment of donor T cells and recells after transplantation expressed the CD45RA isoform constitution of T-cell function but engraftment of few, if any,...
متن کاملPolyclonal reconstitution of human marrow after allogeneic bone marrow transplantation.
Clonal dominance suggestive of reconstitution of marrow from small numbers of pluripotent hematopoietic stem cells has been noted in different experimental and clinical situations. Recipients of human allogeneic marrow transplants have not been previously studied to determine if clonal dominance occurs in this clinical setting. Clonal analysis of 20 allogeneic marrow transplant recipients was p...
متن کاملInterleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation.
Interleukin-15 (IL-15) is a gamma-common cytokine that plays an important role in the development, survival, and proliferation of natural killer (NK), NK T, and CD8+ T-cells. We administered IL-15 to recipients of an allogeneic bone marrow transplantation (allo BMT) to determine its effects on immune reconstitution. Posttransplantation IL-15 administration significantly increased donor-derived ...
متن کاملThe kinetics of immune reconstitution after human marrow transplantation.
Human marrow transplantation for the treatment of malignant and nonmalignant disorders is becoming an established modality of therapy. As in any aggressive therapeutic modality, the benefits must be balanced with the risks of the therapy. The aggressive chemoradiotherapy used to prepare patients for marrow transplantation creates a transient immunodeficiency disorder postgrafting until the tran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1984
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198404001-00981